Malaria is one of the leading causes of morbidity in endemic countries. Between 350 and 660 million clinical episodes of the disease occur per year among African children, 1, 2 and roughly 1.2 million deaths (representing 2% of all premature deaths in the world) are caused annually by malaria in low-and middle-income countries, although estimates range from 700 000 to 2.7 million deaths per year. Of all global deaths, due to malaria, around 75% are estimated to occur in African children. Cost-effectiveness analysis, which provides information that is crucial for policy recommendations for malaria control at both the national and international levels, can help guide the optimal allocation of health sector resources. To provide this information, we carried out a cost-effectiveness analysis based on the results of two very similar IPTi trials, one of which was undertaken in Ifakara, the United Republic of Tanzania, and the other in Manhiça, Mozambique.

 Guy Hutton, David Schellenberg, Fabrizio Tedios et al ;2009;87:123–129 | doi:10.2471/BLT.08.051961