cure 'serif'">Malaria is a leading cause of morbidity and mortality. An estimated 350 and 500 million clinical episodes of malaria occur each year, rx resulting in over one million deaths. Around 60% of the clinical cases and over 90% of the deaths occur in sub-Saharan Africa (Korenromp 2005). In addition to acute disease and deaths, malaria. Because of the high prevalence of malaria and HIV infection in the region, co-infection and interaction between the two diseases are very common. Evidence shows that HIV increases the risk of malaria infection (French 2001), high-density parasitaemia and clinical malaria (Whitworth 2000), and severe malaria and malaria-related mortality (Grimwade 2003; Khasnis 2003). Reports also suggest that anti malarial treatment failure may be more common in HIV-infected adults with low CD4-cell counts compared to those not infected with HIV (Van Geertruyden 2006). In pregnant women, HIV infection has also been shown to impair the ability of pregnant women to control infection with Plasmodium falciparum. HIV-positive pregnant women are more likely to have detectable parasitaemia, higher malaria parasite densities, and develop clinical or placental malaria and malarial anaemia than HIV-negative pregnant women (Ayisi 2003; ter Kuile 2004). 

Mathanga DP, Chinkhumba J; 2007 DOI: 10.1002/14651858.CD006689